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Document type:
journal article 
Author(s):
Krol, J; Francis, RE; Albergaria, A; Sunters, A; Polychronis, A; Coombes, RC; Lam, EW 
Title:
The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells. 
Abstract:
Gefitinib is a specific inhibitor of the epidermal growth factor receptor (EGFR) that causes growth delay in cancer cell lines and human tumor xenografts expressing high levels of EGFR. An understanding of the downstream cellular targets of gefitinib will allow the discovery of biomarkers for predicting outcomes and monitoring anti-EGFR therapies and provide information for key targets for therapeutic intervention. In this study, we investigated the role of FOXO3a in gefitinib action and resista...    »
 
Journal title abbreviation:
Mol Cancer Ther 
Year:
2007 
Journal volume:
Journal issue:
12 Pt 1 
Pages contribution:
3169-79 
Language:
eng 
Print-ISSN:
1535-7163 
TUM Institution:
Frauenklinik und Poliklinik