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Document type:
journal article 
Author(s):
Wirtenberger, M; Schmutzhard, J; Hemminki, K; Meindl, A; Sutter, C; Schmutzler, RK; Wappenschmidt, B; Kiechle, M; Arnold, N; Weber, BH; Niederacher, D; Bartram, CR; Burwinkel, B 
Title:
The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. 
Abstract:
Overexpression of cAMP-dependent protein kinase A (PKA) is a hallmark of the great majority of human cancers including breast cancer. A-kinase anchoring proteins (AKAPs) coordinate the specificity of PKA signalling by localizing the kinase to its subcellular sites. We tested the hypothesis whether the functional amino acid exchange Ile646Val, located in the kinase-binding domain of AKAP10, is a low-penetrance familial breast cancer risk factor. Ile646Val alters the binding of AKAP10 to PKA and i...    »
 
Journal title abbreviation:
Carcinogenesis 
Year:
2007 
Journal volume:
28 
Journal issue:
Pages contribution:
423-6 
Language:
eng 
Print-ISSN:
0143-3334 
TUM Institution:
Frauenklinik und Poliklinik