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- Dokumenttyp:
- Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Frank, B; Hemminki, K; Meindl, A; Wappenschmidt, B; Sutter, C; Kiechle, M; Bugert, P; Schmutzler, RK; Bartram, CR; Burwinkel, B
- Titel:
- BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study.
- Abstract:
- BACKGROUND: Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispose to breast cancer (BC). METHODS: We investigated the effect of BRIP1 -64G>A and Pro919Ser on familial BC risk by means of TaqMan allelic discrimination, analysing BRCA1/BRCA2 mutation-negative index patients of 571 German BC families and 712 control individuals. RESULTS: No sig... »
- Zeitschriftentitel:
- BMC Cancer
- Jahr:
- 2007
- Band / Volume:
- 7
- Seitenangaben Beitrag:
- 83
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1186/1471-2407-7-83
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/17504528
- TUM Einrichtung:
- Frauenklinik und Poliklinik
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