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Document type:
journal article 
Author(s):
Harbeck, N; Schmitt, M; Paepke, S; Allgayer, H; Kates, RE 
Title:
Tumor-associated proteolytic factors uPA and PAI-1: critical appraisal of their clinical relevance in breast cancer and their integration into decision-support algorithms. 
Abstract:
This review considers the past, present, and projected future clinical relevance of the serine protease urokinase-type plasminogen activator (uPA), and its inhibitor, plasminogen activator inhibitor-type 1 (PAI-1), in breast cancer. These factors play a key role in tumor invasion and metastasis in many cancers. In primary breast cancer, their prognostic and predictive impact has been validated at the highest level of evidence by a multicenter therapy trial (Chemo N0) and a large European Organis...    »
 
Journal title abbreviation:
Crit Rev Clin Lab Sci 
Year:
2007 
Journal volume:
44 
Journal issue:
Pages contribution:
179-201 
Language:
eng 
Print-ISSN:
1040-8363 
TUM Institution:
Frauenklinik und Poliklinik