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Document type:
journal article 
Author(s):
Frank, B; Bermejo, JL; Hemminki, K; Sutter, C; Wappenschmidt, B; Meindl, A; Kiechle-Bahat, M; Bugert, P; Schmutzler, RK; Bartram, CR; Burwinkel, B 
Title:
Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. 
Abstract:
Copy number variants (CNVs), insertions, deletions and duplications, contribute considerably to human genetic variation and disease development. A recent study has characterized 100 CNVs including a deletion in the mitochondrial tumor suppressor gene 1 (MTUS1) lacking the coding exon 4. MTUS1 maps to chromosome 8p, a region frequently deleted and associated with disease progression in human cancers, including breast cancer (BC). To investigate the effect of the MTUS1 CNV on familial BC risk, we...    »
 
Journal title abbreviation:
Carcinogenesis 
Year:
2007 
Journal volume:
28 
Journal issue:
Pages contribution:
1442-5 
Language:
eng 
Print-ISSN:
0143-3334 
TUM Institution:
Frauenklinik und Poliklinik