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Document type:
journal article 
Author(s):
Stemmler, HJ; Schmitt, M; Willems, A; Bernhard, H; Harbeck, N; Heinemann, V 
Title:
Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. 
Abstract:
Patients receiving trastuzumab for HER2-overexpressing metastatic breast cancer seem to suffer from an increased risk of brain metastases, even in cases with responsive disease. To evaluate whether trastuzumab is able to penetrate the blood-brain barrier, we measured trastuzumab levels in the serum and in cerebrospinal fluid of metastatic breast cancer patients with brain metastases receiving trastuzumab for HER2-overexpressing metastatic breast cancer. In a pilot study, metastatic breast cancer...    »
 
Journal title abbreviation:
Anticancer Drugs 
Year:
2007 
Journal volume:
18 
Journal issue:
Pages contribution:
23-8 
Language:
eng 
Print-ISSN:
0959-4973 
TUM Institution:
Frauenklinik und Poliklinik; III. Medizinische Klinik und Poliklinik