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Document type:
journal article 
Author(s):
Maier, S; Nimmrich, I; Koenig, T; Eppenberger-Castori, S; Bohlmann, I; Paradiso, A; Spyratos, F; Thomssen, C; Mueller, V; Nährig, J; Schittulli, F; Kates, R; Lesche, R; Schwope, I; Kluth, A; Marx, A; Martens, JW; Foekens, JA; Schmitt, M; Harbeck, N; European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group 
Title:
DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration wit 
Abstract:
Our aim was to identify and validate DNA-methylation markers associated with very good outcome in node negative, hormone receptor positive breast cancer patients after adjuvant endocrine therapy which might allow identifying patients who could be spared the burden of adjuvant chemotherapy. Using a methylation microarray, we analysed 117 candidate genes in hormone receptor-positive tumours from 109 breast cancer patients treated by adjuvant tamoxifen. Results were validated in an independent coho...    »
 
Journal title abbreviation:
Eur J Cancer 
Year:
2007 
Journal volume:
43 
Journal issue:
11 
Pages contribution:
1679-86 
Language:
eng 
Print-ISSN:
0959-8049 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie ; Frauenklinik und Poliklinik