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Document type:
journal article 
Author(s):
Becker-Pauly, C; Höwel, M; Walker, T; Vlad, A; Aufenvenne, K; Oji, V; Lottaz, D; Sterchi, EE; Debela, M; Magdolen, V; Traupe, H; Stöcker, W 
Title:
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation. 
Abstract:
The zinc endopeptidase meprin (EC 3.4.24.18) is expressed in brush border membranes of intestine and kidney tubules, intestinal leukocytes, and certain cancer cells, suggesting a role in epithelial differentiation and cell migration. Here we show by RT-PCR and immunoblotting that meprin is also expressed in human skin. As visualized by immunohistochemistry, the two meprin subunits are localized in separate cell layers of the human epidermis. Meprin alpha is expressed in the stratum basale, where...    »
 
Journal title abbreviation:
J Invest Dermatol 
Year:
2007 
Journal volume:
127 
Journal issue:
Pages contribution:
1115-25 
Language:
eng 
Print-ISSN:
0022-202X 
TUM Institution:
Frauenklinik und Poliklinik