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Dokumenttyp:
journal article 
Autor(en):
Radulescu, RT; Hufnagel, C; Luppa, P; Hellebrand, H; Kuo, WL; Rosner, MR; Harbeck, N; Giersig, C; Meindl, A; Schmitt, M; Weirich, G 
Titel:
Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels. 
Abstract:
Insulin is a hormone crucial to metabolism and an essential growth factor for normal and neoplastic tissues. We have now determined insulin in extracts of 23 primary breast cancer specimens and of non-neoplastic breast tissues by a chemiluminescent immunoassay. Remarkably, insulin was measured only in grade 3 tumors, whereas grade 2 carcinomas and the normal mammary gland were each insulin-negative. We also performed immunohistochemistry for insulin-degrading enzyme (IDE), a cytoplasmic zinc met...    »
 
Zeitschriftentitel:
Int J Oncol 
Jahr:
2007 
Band / Volume:
30 
Heft / Issue:
Seitenangaben Beitrag:
73-80 
Sprache:
eng 
Print-ISSN:
1019-6439 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie; Frauenklinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie