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Dokumenttyp:
journal article 
Autor(en):
Oostendorp, RA; Gilfillan, S; Parmar, A; Schiemann, M; Marz, S; Niemeyer, M; Schill, S; Hammerschmid, E; Jacobs, VR; Peschel, C; Götze, KS 
Titel:
Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells. 
Abstract:
We investigated whether KIT signaling was sufficient to maintain human hematopoietic stem cells in culture or whether, as with murine stem cells, signaling through glycoprotein 130 (gp130) is additionally required. Sorted CD34(+)CD133(+)(CD33/CD38/CD71)(-) cells from human umbilical cord blood (UCB) were cultured in the presence of combinations of KIT-ligand (KL) and the gp130 stimulating molecule oncostatin M (OSM). We found that OSM increased KL-induced proliferation, which was accompanied by...    »
 
Zeitschriftentitel:
Stem Cells 
Jahr:
2008 
Band / Volume:
26 
Heft / Issue:
Seitenangaben Beitrag:
2164-72 
Sprache:
eng 
Print-ISSN:
1066-5099 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Frauenklinik und Poliklinik; r Strahlentherapie und Radiologische Onkologie; r experimentelle Onkologie und Therapieforschung 
Format:
Text