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Document type:
journal article 
Author(s):
Oostendorp, RA; Gilfillan, S; Parmar, A; Schiemann, M; Marz, S; Niemeyer, M; Schill, S; Hammerschmid, E; Jacobs, VR; Peschel, C; Götze, KS 
Title:
Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells. 
Abstract:
We investigated whether KIT signaling was sufficient to maintain human hematopoietic stem cells in culture or whether, as with murine stem cells, signaling through glycoprotein 130 (gp130) is additionally required. Sorted CD34(+)CD133(+)(CD33/CD38/CD71)(-) cells from human umbilical cord blood (UCB) were cultured in the presence of combinations of KIT-ligand (KL) and the gp130 stimulating molecule oncostatin M (OSM). We found that OSM increased KL-induced proliferation, which was accompanied by...    »
 
Journal title abbreviation:
Stem Cells 
Year:
2008 
Journal volume:
26 
Journal issue:
Pages contribution:
2164-72 
Language:
eng 
Print-ISSN:
1066-5099 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Frauenklinik und Poliklinik; r Strahlentherapie und Radiologische Onkologie; r experimentelle Onkologie und Therapieforschung 
Format:
Text