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Document type:
journal article 
Author(s):
Vasiljeva, O; Korovin, M; Gajda, M; Brodoefel, H; Boji?, L; Krüger, A; Schurigt, U; Sevenich, L; Turk, B; Peters, C; Reinheckel, T 
Title:
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. 
Abstract:
Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been positively correlated with mammary tumour progression and metastasis; however, its roles in the hallmark processes of malignant growth remain poorly defined. Using Ctsb-deficient mice we investigated tumour cell differentiation, proliferation and apoptosis in the Tg(MMTV-PyMT) mouse mammary cancer model. Absence of Ctsb significantly impaired development of high-grade invasive ductal carcinomas and reduced the m...    »
 
Journal title abbreviation:
Oncogene 
Year:
2008 
Journal volume:
27 
Journal issue:
30 
Pages contribution:
4191-9 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
r experimentelle Onkologie und Therapieforschung 
Format:
Text