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Document type:
journal article 
Author(s):
Gerg, M; Kopitz, C; Schaten, S; Tschukes, A; Kahlert, C; Stangl, M; Hann von Weyhern, CW; Brücher, BL; Edwards, DR; Brand, K; Krüger, A 
Title:
Distinct Functionality of Tumor Cell-Derived Gelatinases during Formation of Liver Metastases. 
Abstract:
The specific spatiotemporal role of the matrix metalloproteinase 2 (MMP-2) and MMP-9 (gelatinase) during metastasis is still under debate. Host cells have been described as major contributors to these MMPs during metastasis. Here, we show strong overexpression of MMP-2 and MMP-9 by tumor cells of clinical liver specimen of recurrent metachronous metastases, leading us to address the importance of tumor cell-derived MMP-2 or MMP-9 during liver metastasis. Thus far, distinction of their roles was...    »
 
Journal title abbreviation:
Mol Cancer Res 
Year:
2008 
Journal volume:
Journal issue:
Pages contribution:
341-51 
Language:
eng 
Print-ISSN:
1541-7786 
TUM Institution:
r experimentelle Onkologie und Therapieforschung; Chirurgiesche Klinik und Poliklinik