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Document type:
journal article 
Author(s):
Gast, D; Riedle, S; Issa, Y; Pfeifer, M; Beckhove, P; Sanderson, MP; Arlt, M; Moldenhauer, G; Fogel, M; Krüger, A; Altevogt, P 
Title:
The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. 
Abstract:
L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule involved in cell migration and axon guidance in the developing nervous system. L1 is also overexpressed in ovarian and endometrial carcinomas and is associated with a bad prognosis. In carcinoma cell lines, L1 overexpression augments cell motility, tumor growth in mice and induces expression of Erk-dependent genes. Here, we show that a mutation in the cytoplasmic portion of L1 (T1247A, S1248A) abrogates Erk activation,...    »
 
Journal title abbreviation:
Oncogene 
Year:
2008 
Journal volume:
27 
Journal issue:
Pages contribution:
1281-9 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung