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Document type:
journal article 
Author(s):
Jahnke, A; Hirschberger, J; Fischer, C; Brill, T; Köstlin, R; Plank, C; Küchenhoff, H; Krieger, S; Kamenica, K; Schillinger, U 
Title:
Intra-tumoral gene delivery of feIL-2, feIFN-gamma and feGM-CSF using magnetofection as a neoadjuvant treatment option for feline fibrosarcomas: a phase-I study. 
Abstract:
Despite aggressive pre- or postoperative treatment, feline fibrosarcomas have a high relapse rate. In this study, a new treatment option based on immune stimulation by intra-tumoral delivery of three feline cytokine genes was performed. The objective of this phase-I dose-escalation study was to determine a safe dose for further evaluation in a subsequent phase-II trial. Twenty-five client-owned cats with clinical diagnosis of fibrosarcoma - primary tumours as well as recurrences - entered the st...    »
 
Journal title abbreviation:
J Vet Med A Physiol Pathol Clin Med 
Year:
2007 
Journal volume:
54 
Journal issue:
10 
Pages contribution:
599-606 
Language:
eng 
Print-ISSN:
0931-184X 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung