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Dokumenttyp:
journal article 
Autor(en):
Laumen, H; Skurk, T; Hauner, H 
Titel:
The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes. 
Abstract:
Human preadipocytes and adipocytes are known to produce the proatherogenic factor PAI-1 and proinflammatory cytokines, and obesity was found to be state of increased adipose production of these factors. In the present study, we investigated the effect of rosuvastatin on the regulation of PAI-1 gene expression in human adipocytes. Human preadipocytes, adipocytes in primary culture and the SGBS cell line were used as cell models. Cells were transfected using various constructs and promoter activit...    »
 
Zeitschriftentitel:
Atherosclerosis 
Jahr:
2008 
Band / Volume:
196 
Heft / Issue:
Seitenangaben Beitrag:
565-73 
Sprache:
eng 
Print-ISSN:
0021-9150 
TUM Einrichtung:
hrungsmedizin