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Document type:
journal article 
Author(s):
Braren, I; Blank, S; Seismann, H; Deckers, S; Ollert, M; Grunwald, T; Spillner, E 
Title:
Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries. 
Abstract:
BACKGROUND: Allergen-specific IgE and IgG antibodies play pivotal roles in the induction and progression of allergic hypersensitivity reactions. Consequently, monoclonal human IgE and IgG4 antibodies with defined specificity for allergens should be useful in allergy research and diagnostic tests. We used combinatorial antibody libraries and subsequent recombinant production to make and assess IgE, IgG1, and IgG4 allergen-specific antibodies. METHODS: We used phage display to select a synthetic s...    »
 
Journal title abbreviation:
Clin Chem 
Year:
2007 
Journal volume:
53 
Journal issue:
Pages contribution:
837-44 
Language:
eng 
Print-ISSN:
0009-9147 
TUM Institution:
r Dermatologie und Allergologie