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Dokumenttyp:
journal article 
Autor(en):
Braren, I; Blank, S; Seismann, H; Deckers, S; Ollert, M; Grunwald, T; Spillner, E 
Titel:
Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries. 
Abstract:
BACKGROUND: Allergen-specific IgE and IgG antibodies play pivotal roles in the induction and progression of allergic hypersensitivity reactions. Consequently, monoclonal human IgE and IgG4 antibodies with defined specificity for allergens should be useful in allergy research and diagnostic tests. We used combinatorial antibody libraries and subsequent recombinant production to make and assess IgE, IgG1, and IgG4 allergen-specific antibodies. METHODS: We used phage display to select a synthetic s...    »
 
Zeitschriftentitel:
Clin Chem 
Jahr:
2007 
Band / Volume:
53 
Heft / Issue:
Seitenangaben Beitrag:
837-44 
Sprache:
eng 
Print-ISSN:
0009-9147 
TUM Einrichtung:
r Dermatologie und Allergologie