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Document type:
journal article 
Author(s):
Lim, A; Luderschmidt, S; Weidinger, A; Schnopp, C; Ring, J; Hein, R; Ollert, M; Mempel, M 
Title:
The IgE repertoire in PBMCs of atopic patients is characterized by individual rearrangements without variable region of the heavy immunoglobulin chain bias. 
Abstract:
BACKGROUND: Patients with atopic diseases are characterized by high levels of specific IgE production. However, little is known about the composition of their B-cell repertoires. OBJECTIVES: We sought to analyze the complete PBMC-derived IgE repertoire and to compare clonal expansions between different patients. METHODS: We have analyzed the IgE-bearing B-cell receptor repertoire in highly atopic patients (>1000 IU/mL) using quantitative RT-PCR, complementarity determining region 3 spectratyping...    »
 
Journal title abbreviation:
J Allergy Clin Immunol 
Year:
2007 
Journal volume:
120 
Journal issue:
Pages contribution:
696-706 
Language:
eng 
Print-ISSN:
0091-6749 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie