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Document type:
journal article 
Author(s):
Michalski, CW; Gorbachevski, A; Erkan, M; Reiser, C; Deucker, S; Bergmann, F; Giese, T; Weigand, M; Giese, NA; Friess, H; Kleeff, J 
Title:
Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis. 
Abstract:
BACKGROUND: Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP). METHODS: Markers of fibrosis and inflammation were concomitantly analysed by immunohistochemistry in chronic pancreatitis tissues. In vitro, PSC were stimulated with TNFalpha and LPS. Primary human blood mononuclear cells (PBMC) and PSC were cocultured, followed by analysis of cytokines and extracell...    »
 
Journal title abbreviation:
J Transl Med 
Year:
2007 
Journal volume:
Pages contribution:
63 
Language:
eng 
TUM Institution:
Chirurgiesche Klinik und Poliklinik