Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Michalski, CW; Gorbachevski, A; Erkan, M; Reiser, C; Deucker, S; Bergmann, F; Giese, T; Weigand, M; Giese, NA; Friess, H; Kleeff, J 
Titel:
Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis. 
Abstract:
BACKGROUND: Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP). METHODS: Markers of fibrosis and inflammation were concomitantly analysed by immunohistochemistry in chronic pancreatitis tissues. In vitro, PSC were stimulated with TNFalpha and LPS. Primary human blood mononuclear cells (PBMC) and PSC were cocultured, followed by analysis of cytokines and extracell...    »
 
Zeitschriftentitel:
J Transl Med 
Jahr:
2007 
Band / Volume:
Seitenangaben Beitrag:
63 
Sprache:
eng 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik