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Document type:
journal article 
Author(s):
Hennig, R; Kehl, T; Noor, S; Ding, XZ; Rao, SM; Bergmann, F; Fürstenberger, G; Büchler, MW; Friess, H; Krieg, P; Adrian, TE 
Title:
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth. 
Abstract:
Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been suggested as a tumor promoter in pancreatic carcinogenesis. Here we provide evidence that 15-lipoxygenase-1 (15-LOX-1) expression and activity may exert antitumorigenic effects in pa...    »
 
Journal title abbreviation:
Neoplasia 
Year:
2007 
Journal volume:
Journal issue:
11 
Pages contribution:
917-26 
Language:
eng 
Print-ISSN:
1522-8002 
TUM Institution:
Chirurgiesche Klinik und Poliklinik