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Document type:
journal article 
Author(s):
Weber, GF; Schlautkötter, S; Kaiser-Moore, S; Altmayr, F; Holzmann, B; Weighardt, H 
Title:
Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis. 
Abstract:
Interleukin-22 (IL-22) is a recently discovered proinflammatory cytokine, structurally related to IL-10. Since IL-22 is induced by lipopolysaccharide in vivo, we studied the role of IL-22 in a model of polymicrobial peritonitis. Quantitative real-time reverse transcription-PCR analysis showed marked induction of IL-22 and IL-22 receptor in spleen and kidney during the course of sepsis. The biological activity of IL-22 is modulated by IL-22-binding protein (IL-22BP), which is considered a natural...    »
 
Journal title abbreviation:
Infect Immun 
Year:
2007 
Journal volume:
75 
Journal issue:
Pages contribution:
1690-7 
Language:
eng 
Print-ISSN:
0019-9567 
TUM Institution:
Chirurgiesche Klinik und Poliklinik