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Document type:
journal article 
Author(s):
Michalski, CW; Shi, X; Reiser, C; Fachinger, P; Zimmermann, A; Büchler, MW; Di Sebastiano, P; Friess, H 
Title:
Neurokinin-2 receptor levels correlate with intensity, frequency, and duration of pain in chronic pancreatitis. 
Abstract:
OBJECTIVE: Generation and maintenance of pain in chronic pancreatitis (CP) have been shown to be partially attributable to neuroimmune interactions, which involve neuropeptides such as substance P (SP). So far, expression of SP receptors NK-2R, NK-3R, the SP-encoding gene preprotachykinin A (PPT-A), and the SP degradation enzyme neutral endopeptidase (NEP) and their relation to pain in CP have not been determined. METHODS: Tissue samples from patients with CP (n = 25) and from healthy donors (n...    »
 
Journal title abbreviation:
Ann Surg 
Year:
2007 
Journal volume:
246 
Journal issue:
Pages contribution:
786-93 
Language:
eng 
Print-ISSN:
0003-4932 
TUM Institution:
Chirurgiesche Klinik und Poliklinik