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Dokumenttyp:
journal article 
Autor(en):
Vignjevic, D; Schoumacher, M; Gavert, N; Janssen, KP; Jih, G; Laé, M; Louvard, D; Ben-Ze'ev, A; Robine, S 
Titel:
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. 
Abstract:
Cancer cells become metastatic by acquiring a motile and invasive phenotype. This step requires remodeling of the actin cytoskeleton and the expression of exploratory, sensory organelles known as filopodia. Aberrant beta-catenin-TCF target gene activation plays a major role in colorectal cancer development. We identified fascin1, a key component of filopodia, as a target of beta-catenin-TCF signaling in colorectal cancer cells. Fascin1 mRNA and protein expression were increased in primary cancer...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2007 
Band / Volume:
67 
Heft / Issue:
14 
Seitenangaben Beitrag:
6844-53 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik