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Document type:
journal article 
Author(s):
Vignjevic, D; Schoumacher, M; Gavert, N; Janssen, KP; Jih, G; Laé, M; Louvard, D; Ben-Ze'ev, A; Robine, S 
Title:
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. 
Abstract:
Cancer cells become metastatic by acquiring a motile and invasive phenotype. This step requires remodeling of the actin cytoskeleton and the expression of exploratory, sensory organelles known as filopodia. Aberrant beta-catenin-TCF target gene activation plays a major role in colorectal cancer development. We identified fascin1, a key component of filopodia, as a target of beta-catenin-TCF signaling in colorectal cancer cells. Fascin1 mRNA and protein expression were increased in primary cancer...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2007 
Journal volume:
67 
Journal issue:
14 
Pages contribution:
6844-53 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Chirurgiesche Klinik und Poliklinik