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Document type:
journal article 
Author(s):
Kopitz, C; Gerg, M; Bandapalli, OR; Ister, D; Pennington, CJ; Hauser, S; Flechsig, C; Krell, HW; Antolovic, D; Brew, K; Nagase, H; Stangl, M; von Weyhern, CW; Brücher, BL; Brand, K; Coussens, LM; Edwards, DR; Krüger, A 
Title:
Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. 
Abstract:
Balanced expression of proteases and their inhibitors is one prerequisite of tissue homeostasis. Metastatic spread of tumor cells through the organism depends on proteolytic activity and is the death determinant for cancer patients. Paradoxically, increased expression of tissue inhibitor of metalloproteinases-1 (TIMP-1), a natural inhibitor of several endometalloproteinases, including matrix metalloproteinases and a disintegrin and metalloproteinase-10 (ADAM-10), in cancer patients is negatively...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2007 
Journal volume:
67 
Journal issue:
18 
Pages contribution:
8615-23 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
r experimentelle Onkologie und Therapieforschung; Chirurgiesche Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie; r Klinische Chemie und Pathobiochemie