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Document type:
journal article 
Author(s):
Napieralski, R; Ott, K; Kremer, M; Becker, K; Boulesteix, AL; Lordick, F; Siewert, JR; Höfler, H; Keller, G 
Title:
Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: relation to therapy response and clinicopathologic and molecular features. 
Abstract:
PURPOSE: The objective of this study was to analyze the hypermethylation of tumor-related gene promoters for an association with therapy response and clinicopathologic features of neoadjuvant-treated gastric cancer patients. Furthermore, we analyzed the relationship of promoter hypermethylation with microsatellite instability and loss of heterozygosity (LOH) of the tumors. EXPERIMENTAL DESIGN: Pretherapeutic biopsies of 61 patients, subsequently treated with cisplatin and 5-fluorouracil, were st...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2007 
Journal volume:
13 
Journal issue:
17 
Pages contribution:
5095-102 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie ; Chirurgiesche Klinik und Poliklinik ; III. Medizinische Klinik und Poliklinik