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Document type:
journal article 
Author(s):
Langer, R; Specht, K; Becker, K; Ewald, P; Ott, K; Lordick, F; Siewert, JR; Höfler, H 
Title:
Comparison of pretherapeutic and posttherapeutic expression levels of chemotherapy-associated genes in adenocarcinomas of the esophagus treated by 5-fluorouracil- and cisplatin-based neoadjuvant chemotherapy. 
Abstract:
We analyzed expression of genes associated with metabolism of chemotherapeutic drugs in locally advanced esophageal adenocarcinomas before and after neoadjuvant chemotherapy to study whether there is a change in gene expression induced by chemotherapy and whether such changes are associated with tumor response or nonresponse. We included 21 patients with locally advanced esophageal adenocarcinomas treated by cisplatin- and 5-fluorouracil (5-FU)-based neoadjuvant chemotherapy before surgery. Mess...    »
 
Journal title abbreviation:
Am J Clin Pathol 
Year:
2007 
Journal volume:
128 
Journal issue:
Pages contribution:
191-7 
Language:
eng 
Print-ISSN:
0002-9173 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie ; Chirurgiesche Klinik und Poliklinik ; III. Medizinische Klinik und Poliklinik