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Dokumenttyp:
journal article 
Autor(en):
Dorn, T; Kuhn, U; Bungartz, G; Stiller, S; Bauer, M; Ellwart, J; Peters, T; Scharffetter-Kochanek, K; Semmrich, M; Laschinger, M; Holzmann, B; Klinkert, WE; Straten, PT; Køllgaard, T; Sixt, M; Brakebusch, C 
Titel:
RhoH is important for positive thymocyte selection and T-cell receptor signaling. 
Abstract:
RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Furthermore, the differentiation and expansion of DN3 and DN4 thymocytes in vitro were severely impaired. These defects corresponded to defective TCR signaling. Although RhoH is not required for TCR-induced activation of ZAP70 and ZAP70-mediated a...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2007 
Band / Volume:
109 
Heft / Issue:
Seitenangaben Beitrag:
2346-55 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik