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Document type:
journal article 
Author(s):
Engelhard, K; Werner, C; Eberspächer, E; Bachl, M; Blobner, M; Hildt, E; Hutzler, P; Kochs, E 
Title:
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. 
Abstract:
In this study, we investigated whether the neuroprotection previously seen with dexmedetomidine or S(+)-ketamine involves regulation of proapoptotic (Bax and p53) and antiapoptotic (Bcl-2 and Mdm-2) proteins. Rats were anesthetized with isoflurane. After surgical preparation of isoflurane was discontinued, animals were randomly assigned to receive fentanyl and nitrous oxide (N(2)O)/oxygen plus 100 microg/kg of dexmedetomidine intraperitoneally 30 min before ischemia (n = 8), 1 mg x kg(-1) x min(...    »
 
Journal title abbreviation:
Anesth Analg 
Year:
2003 
Journal volume:
96 
Journal issue:
Pages contribution:
524-31, table of contents 
Language:
eng 
Print-ISSN:
0003-2999 
TUM Institution:
Klinik für Anästhesiologie; Institut für experimentelle Onkologie und Therapieforschung