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Document type:
journal article 
Author(s):
Fink, H; Luppa, P; Mayer, B; Rosenbrock, H; Metzger, J; Martyn, JA; Blobner, M 
Title:
Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors. 
Abstract:
BACKGROUND: Systemic inflammation may be associated with resistance to nondepolarizing neuromuscular blocking drugs, the mechanisms of which are, however, uncharacterized. The authors therefore investigated the pharmacodynamics of atracurium and its relation to the expression of nicotinic acetylcholine receptors and alpha1 -acid glycoprotein in a rat model of systemic inflammation. METHODS: To induce a systemic inflammation, male CD rats received 56 mg/kg corynebacterium parvum intravenously. On...    »
 
Journal title abbreviation:
Anesthesiology 
Year:
2003 
Journal volume:
98 
Journal issue:
Pages contribution:
82-8 
Language:
eng 
Print-ISSN:
0003-3022 
TUM Institution:
Klinik für Anästhesiologie; Institut für Klinische Chemie und Pathobiochemie