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Document type:
journal article 
Author(s):
Gertler, Ralph; Gruber, Michael; Grassin-Delyle, Stanislas; Urien, Saïk; Martin, Klaus; Tassani-Prell, Peter; Braun, Siegmund; Burg, Simon; Wiesner, Gunther 
Title:
Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery. 
Abstract:
Tranexamic acid (TXA) continues to be one of the antifibrinolytics of choice during paediatric cardiac surgery. However, in infants less than 1 year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion.Forty-three children less than 1 year of age were enrolled, of whom 37 required the use of cardiopulmonary bypass (CPB) and six were operated on without CPB. Administration of 50 mg kg TXA intravenously at the induction of anaesthesia was followed by 50...    »
 
Journal title abbreviation:
Br J Clin Pharmacol 
Year:
2017 
Journal volume:
83 
Journal issue:
Pages contribution:
1745-1757 
Language:
eng 
Print-ISSN:
0306-5251 
TUM Institution:
Institut für Laboratoriumsmedizin