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Document type:
journal article 
Author(s):
Foin, Nicolas; Lu, Shengjie; Ng, Jaryl; Bulluck, Heerajnarain; Hausenloy, Derek J; Wong, Philip E; Virmani, Renu; Joner, Michael 
Title:
Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model. 
Abstract:
The aim of this report was to examine the effect of underexpansion on stent thrombogenicity with an in vitro perfusion model.Drug-eluting stent (DES) samples were partially underdeployed in silicone tubes and perfused with porcine blood containing 10% anticoagulant citrate dextrose solution for four minutes at a flow rate of 200 ml/min. Thrombus formation was evaluated and compared between the well-apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well-apposed sections (13.9 vs. 0.41 mm2, p<0.001).Stent malapposition has a very direct impact on thrombus formation. Optimised stent implantation is required to minimise malapposition in DES and BVS to reduce thrombus formation. 
Journal title abbreviation:
EuroIntervention 
Year:
2017 
Journal volume:
13 
Journal issue:
Pages contribution:
e1096-e1098 
Language:
eng 
Print-ISSN:
1774-024X 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen