Twelve-month outcomes after bioresorbable vascular scaffold implantation in patients with acute coronary syndromes. Data from the European Multicenter GHOST-EU Extended Registry.

Schnorbus, Boris; Wiebe, Jens; Capodanno, Davide; Brugaletta, Salvatore; Geraci, Salvatore; Mehilli, Julinda; Latib, Azeem; Lesiak, Maciej; Jensen, Christoph; Mattesini, Alessio; Münzel, Thomas; Capranzano, Piera; Di Mario, Carlo; Naber, Christoph; Araszkiewicz, Aleksander; Colombo, Antonio; Caramanno, Giuseppe; Sabaté, Manel; Tamburino, Corrado; Nef, Holger; Gori, Tommaso

doi:10.4244/EIJ-D-16-00568

Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)

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Dokumenttyp:: Journal Article
Autor(en):: Schnorbus, Boris; Wiebe, Jens; Capodanno, Davide; Brugaletta, Salvatore; Geraci, Salvatore; Mehilli, Julinda; Latib, Azeem; Lesiak, Maciej; Jensen, Christoph; Mattesini, Alessio; Münzel, Thomas; Capranzano, Piera; Di Mario, Carlo; Naber, Christoph; Araszkiewicz, Aleksander; Colombo, Antonio; Caramanno, Giuseppe; Sabaté, Manel; Tamburino, Corrado; Nef, Holger; Gori, Tommaso
Titel:: Twelve-month outcomes after bioresorbable vascular scaffold implantation in patients with acute coronary syndromes. Data from the European Multicenter GHOST-EU Extended Registry.
Abstract:: The aim of this study was to report on the midterm outcomes of patients undergoing percutaneous coronary intervention with bioresorbable vascular scaffolds (BVS) for the treatment of acute coronary syndromes (ACS) and compare with those of patients with stable coronary artery disease (sCAD).One thousand four hundred and seventy-seven (1,477) patients underwent implantation of one or more BVS (Absorb BVS; Abbott Vascular, Santa Clara, CA, USA) at 11 European centres and were included in the GHOST-EU registry. Admissions comprised 47.1% of the patients (951 BVS) with ACS, and 52.8% (1,274 BVS) with sCAD. During a median follow-up of 384 (359-460) days, patient-oriented endpoints (PoCE), including all-cause death, any infarction, any revascularisation, were recorded in 271 patients (12-month incidence in ACS patients: 18.5% vs. 11.6% in the sCAD group, p<0.001). Device-oriented composite endpoints (DoCE), cardiac death, target vessel infarction and target lesion revascularisation, were observed in 98 patients (12-month incidence of 4.2% in the sCAD group, 6.4% in the ACS group; p=0.052). The 12-month incidence of definite scaffold thrombosis was 2.6% in ACS patients and 0.8% in XIENCE patients (p=0.006). In multivariate analysis, ACS was a predictor of DoCE (HR: 2.26 [1.34-3.81], p=0.002), PoCE (HR: 1.71 [1.13-2.58], p=0.011), and stent thrombosis (HR: 2.51 [1.13-5.60], p=0.025). In contrast, the incidence of target lesion revascularisation was not different between groups. There was no difference in the incidence of any of these endpoints among the different clinical presentations (unstable angina, non-ST-elevation infarction and ST-elevation infarction).PoCE, DoCE and scaffold thromboses were more frequent in ACS patients, without any difference among different forms of ACS.
Zeitschriftentitel:: EuroIntervention
Jahr:: 2017
Band / Volume:: 13
Heft / Issue:: 9
Seitenangaben Beitrag:: e1104-e1111
Sprache:: eng
Volltext / DOI:: doi:10.4244/EIJ-D-16-00568
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/28320687
Print-ISSN:: 1774-024X
TUM Einrichtung:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2017