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- Dokumenttyp:
- Journal Article
- Autor(en):
- Vitanova, Keti; Wirth, Felix; Boehm, Johannes; Burri, Melchior; Lange, Rüdiger; Krane, Markus
- Titel:
- Surgical Aortic Valve Replacement-Age-Dependent Choice of Prosthesis Type.
- Abstract:
- BACKGROUND: Recently, the use of surgically implanted aortic bioprostheses has been favoured in younger patients. We aimed to analyse the long-term survival and postoperative MACCE (Major Adverse Cardiovascular and Cerebral Event) rates in patients after isolated aortic valve replacement. METHODS: We conducted a single-centre observational retrospective study, including all consecutive patients with isolated aortic valve replacement. 1:1 propensity score matching of the preoperative baseline characteristics was performed. RESULTS: A total of 2172 patients were enrolled in the study. After propensity score matching the study included 428 patients: 214 biological vs. 214 mechanical prostheses, divided into two subgroups: group A < 60 years and group B > 60 years. The mean follow-up time was 7.6 ± 3.9 years. Estimated survival was 97 ± 1.9% and 89 ± 3.4% at 10 years for biological and mechanical prosthesis, respectively in group A (p = 0.06). In group B the survival at 10 years was 79.1 ± 5.8% and 69.8 ± 4.4% for biological and mechanical prosthesis, respectively (p = 0.83). In group A, patients with a bioprosthesis exhibited a tendency for higher cumulative incidence MACCE rates compared to patients with a mechanical prosthesis, p = 0.83 (bio 7.3 ± 5.3% vs. mech 4.6 ± 2.2% at 10 years). In group B, patients with a mechanical prosthesis showed a tendency for higher cumulative incidence MACCE rates compared to patients with bioprosthesis, p = 0.86 (bio 4.3 ± 3.1% vs. mech 9.1 ± 3.1% at 10 years). CONCLUSIONS: Long-term survival after surgical aortic valve replacement is similar in patients with a biological and mechanical prosthesis, independent of the patients' age. Moreover, younger patients (<60 years) with bioprosthesis showed a survival benefit, compared to patients with mechanical prosthesis in this age group.
- Zeitschriftentitel:
- J Clin Med
- Jahr:
- 2021
- Band / Volume:
- 10
- Heft / Issue:
- 23
- Volltext / DOI:
- doi:10.3390/jcm10235554
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/34884256
- TUM Einrichtung:
- Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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