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Document type:
journal article 
Author(s):
Kranawetvogl, Andreas; Siegert, Markus; Eyer, Florian; Thiermann, Horst; John, Harald 
Title:
Verification of organophosphorus pesticide poisoning: Detection of phosphorylated tyrosines and a cysteine-proline disulfide-adduct from human serum albumin after intoxication with dimethoate/omethoate. 
Abstract:
A method is described allowing forensic analysis of plasma samples to prove human poisoning with the organophosphorus pesticides omethoate (OM) and dimethoate (DIM). Upon incubation of human serum albumin (HSA) with both pesticides tyrosine residues were phosphorylated. In addition, a novel disulfide-adduct between the identical thiol-containing leaving group of OM and DIM (2-mercapto-N-methylacetamide, MNMA) and the only free cysteine residue in HSA (Cys) was formed. Following pronase-catalyzed...    »
 
Journal title abbreviation:
Toxicol Lett 
Year:
2018 
Journal volume:
299 
Pages contribution:
11-20 
Language:
eng 
Print-ISSN:
0378-4274 
TUM Institution:
Abteilung für Klinische Toxikologie