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Document type:
journal article 
Author(s):
Lorentzen, Anna; Becker, Paul F; Kosla, Jan; Saini, Massimo; Weidele, Kathrin; Ronchi, Paolo; Klein, Corinna; Wolf, Monika J; Geist, Felix; Seubert, Bastian; Ringelhan, Marc; Mihic-Probst, Daniela; Esser, Knud; Roblek, Marko; Kuehne, Felix; Bianco, Gaia; O'Connor, Tracy; Müller, Quentin; Schuck, Kathleen; Lange, Sebastian; Hartmann, Daniel; Spaich, Saskia; Groß, Olaf; Utikal, Jochen; Haferkamp, Sebastian; Sprick, Martin R; Damle-Vartak, Amruta; Hapfelmeier, Alexander; Hüser, Norbert; Protzer, Ul...    »
 
Title:
Single cell polarity in liquid phase facilitates tumour metastasis. 
Abstract:
Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2018 
Journal volume:
Journal issue:
Pages contribution:
887 
Language:
eng 
TUM Institution:
Institut für Virologie