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Document type:
journal article 
Author(s):
Borchard, Sabine; Bork, Francesca; Rieder, Tamara; Eberhagen, Carola; Popper, Bastian; Lichtmannegger, Josef; Schmitt, Sabine; Adamski, Jerzy; Klingenspor, Martin; Weiss, Karl-Heinz; Zischka, Hans 
Title:
The exceptional sensitivity of brain mitochondria to copper. 
Abstract:
Wilson disease (WD) is characterized by a disrupted copper homeostasis resulting in dramatically increased copper levels, mainly in liver and brain. While copper damage to mitochondria is an established feature in WD livers, much less is known about such detrimental copper effects in other organs. We therefore assessed the mitochondrial sensitivity to copper in a tissue specific manner, namely of isolated rat liver, kidney, heart, and brain mitochondria. Brain mitochondria presented with excepti...    »
 
Journal title abbreviation:
Toxicol In Vitro 
Year:
2018 
Journal volume:
51 
Pages contribution:
11-22 
Language:
eng 
Print-ISSN:
0887-2333 
TUM Institution:
Institut für Toxikologie und Umwelthygiene