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Document type:
journal article 
Author(s):
Zischka, Hans; Einer, Claudia 
Title:
Mitochondrial copper homeostasis and its derailment in Wilson disease. 
Abstract:
In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent on adequate copper supply for proper respiratory function, and the molecular mechanisms for metalation of the cytochrome c oxidase have been largely characterized. On the other hand, copper overload impairs mitochondria and uncertainties exist co...    »
 
Journal title abbreviation:
Int J Biochem Cell Biol 
Year:
2018 
Journal volume:
102 
Pages contribution:
71-75 
Language:
eng 
Print-ISSN:
1357-2725 
TUM Institution:
Institut für Toxikologie und Umwelthygiene