User: Guest  Login
Document type:
journal article 
Author(s):
Müller, Jennifer-Christin; Lichtmannegger, Josef; Zischka, Hans; Sperling, Michael; Karst, Uwe 
Title:
High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment. 
Abstract:
Wilson disease (WD) is a rare genetic disorder of the copper metabolism leading to systemic copper accumulation, predominantly in the liver. The therapeutic approach in WD patients is the generation of a negative copper balance and the maintenance of copper homeostasis, currently by the use of copper chelators such as D-penicillamine (D-PA). However, in circumstances of delayed diagnosis, poor treatment compliance, or treatment failure, mortality is almost certain without hepatic transplantation...    »
 
Journal title abbreviation:
J Trace Elem Med Biol 
Year:
2018 
Journal volume:
49 
Pages contribution:
119-127 
Language:
eng 
Print-ISSN:
0946-672X 
TUM Institution:
Institut für Toxikologie und Umwelthygiene