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Document type:
journal article 
Author(s):
Muller, Jennifer-C; Lichtmannegger, Josef; Zischka, Hans; Sperling, Michael; Karst, Uwe 
Title:
High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment. 
Abstract:
Wilson disease (WD) is a rare genetic disorder of the copper metabolism leading to systemic copper accumulation, predominantly in the liver. The therapeutic approach in WD patients is the generation of a negative copper balance and the maintenance of copper homeostasis, currently by the use of copper chelators such as D-penicillamine (D-PA). However, in circumstances of delayed diagnosis, poor treatment compliance, or treatment failure, mortality is almost certain without hepatic transplantation...    »
 
Journal title abbreviation:
Journal of trace elements in medicine and biology : organ of the Society 
Year:
2018 
Journal volume:
49 
Pages contribution:
119-127 
Language:
eng 
Print-ISSN:
29895360 
TUM Institution:
Institut für Toxikologie und Umwelthygiene