Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schober, Kilian; Buchholz, Veit R; Busch, Dirk H 
Titel:
TCR repertoire evolution during maintenance of CMV-specific T-cell populations. 
Abstract:
During infections and cancer, the composition of the T-cell receptor (TCR) repertoire of antigen-specific CD8 T cells changes over time. TCR avidity is thought to be a major driver of this process, thereby interacting with several additional regulators of T-cell responses to form a composite immune response architecture. Infections with latent viruses, such as cytomegalovirus (CMV), can lead to large T-cell responses characterized by an oligoclonal TCR repertoire. Here, we review the current sta...    »
 
Zeitschriftentitel:
Immunol Rev 
Jahr:
2018 
Band / Volume:
283 
Heft / Issue:
Seitenangaben Beitrag:
113-128 
Sprache:
eng 
Print-ISSN:
0105-2896 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene