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Dokumenttyp:
journal article 
Autor(en):
Bara, Jennifer J; Dresing, Iska; Zeiter, Stephan; Anton, Martina; Daculsi, Guy; Eglin, David; Nehrbass, Dirk; Stadelmann, Vincent A; Betts, Duncan C; Müller, Ralph; Alini, Mauro; Stoddart, Martin J 
Titel:
A doxycycline inducible, adenoviral BMP-2 gene delivery system to bone. 
Abstract:
We report the novel use of a tuneable, non-integrating viral gene delivery system to bone that can be combined with clinically approved biomaterials in an'off-the shelf' manner. Specifically, a doxycycline inducible Tet-on adenoviral vector (AdTetBMP-2) in combination with mesenchymal stromal cells (MSCs), fibrin and a biphasic calcium phosphate ceramic (MBCP®) was used to repair large bone defects in nude rats. BMP-2 transgene expression could be effectively tuned by modification of doxycycline...    »
 
Zeitschriftentitel:
J Tissue Eng Regen Med 
Jahr:
2016 
Sprache:
eng 
Print-ISSN:
1932-6254 
TUM Einrichtung:
Institut für experimentelle Onkologie und Therapieforschung