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Dokumenttyp:
journal article 
Autor(en):
Heine, Annkristin; Schilling, Judith; Grünwald, Barbara; Krüger, Achim; Gevensleben, Heidrun; Held, Stefanie Andrea Erika; Garbi, Natalio; Kurts, Christian; Brossart, Peter; Knolle, Percy; Diehl, Linda; Höchst, Bastian 
Titel:
The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib. 
Abstract:
Increased numbers of immunosuppressive myeloid derived suppressor cells (MDSCs) correlate with a poor prognosis in cancer patients. Tyrosine kinase inhibitors (TKIs) are used as standard therapy for the treatment of several neoplastic diseases. However, TKIs not only exert effects on the malignant cell clone itself but also affect immune cells. Here, we investigate the effect of TKIs on the induction of MDSCs that differentiate from mature human monocytes using a new in vitro model of MDSC induc...    »
 
Zeitschriftentitel:
Cancer Immunol Immunother 
Jahr:
2016 
Band / Volume:
65 
Heft / Issue:
Seitenangaben Beitrag:
273-82 
Sprache:
eng 
Print-ISSN:
0340-7004 
TUM Einrichtung:
Institut für experimentelle Onkologie und Therapieforschung; Institut für Molekulare Immunologie