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Document type:
journal article 
Author(s):
Bittersohl, Heike; Schniedewind, Björn; Christians, Uwe; Luppa, Peter B 
Title:
A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples. 
Abstract:
Therapeutic drug monitoring (TDM) of the immunosuppressive drug tacrolimus is essential to avoid side effects and rejection of the allograft after transplantation. In the blood circulation, tacrolimus is largely located inside erythrocytes or bound to plasma proteins and less than 0.1% is protein-unbound (free). One basic principle of clinical pharmacology is that only free drug is pharmacologically active and monitoring this portion has the potential to better reflect the drug effect than conve...    »
 
Journal title abbreviation:
J Chromatogr A 
Year:
2018 
Journal volume:
1547 
Pages contribution:
45-52 
Language:
eng 
Print-ISSN:
0021-9673 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie