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Document type:
journal article 
Author(s):
Grimmer, Timo; Shi, Kuangyu; Diehl-Schmid, Janine; Natale, Bianca; Drzezga, Alexander; Förster, Stefan; Förstl, Hans; Schwaiger, Markus; Yakushev, Igor; Wester, Hans-Jürgen; Kurz, Alexander; Yousefi, Behrooz Hooshyar 
Title:
F-FIBT may expand PET for ?-amyloid imaging in neurodegenerative diseases. 
Abstract:
F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image ?-amyloid depositions (A?) in humans in-vivo that binds to A? with excellent affinity (K 0.7 ± 0.2) and high selectivity over tau and ?-synuclein aggregates (Ki> 1000 nM). We aimed to characterize F-FIBT in a series of patients with different clinical-pathophysiological phenotypes and to compare its binding characteristics to the refe...    »
 
Journal title abbreviation:
Mol Psychiatry 
Year:
2018 
Language:
eng 
Print-ISSN:
1359-4184 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie