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Original title:
Inzidenz allergischer Reaktionen auf Aprotinin in der Herzchirurgie - eine Analyse von 12403 Aprotininexpositionen 
Translated title:
Incindence of anaphylactic reactions to Aprotinin – an analysis of 12403 exposures to Aprotinin in cardiac surgery 
Year:
2008 
Document type:
Dissertation 
Institution:
Fakultät für Medizin 
Advisor:
Dietrich, Wulf A. W.(Prof. Dr.) 
Referee:
Dietrich, Wulf A. W.(Prof. Dr.) 
Language:
de 
Subject group:
MED Medizin 
Keywords:
Aprotinin, Allergische Reaktion, Allergie 
Abstract:
Aprotinin ist ein unspezifischer Proteaseninhibitor und wird in der Herzchirurgie aufgrund seiner blutungsverringernden Wirkung häufig verwendet. Als tierisches Eiweiß besitzt es antigene Eigenschaften und kann allergische Reaktionen auslösen. Ziel vorliegender Arbeit ist es, die Inzidenz und den Schweregrad allergischer Reaktionen auf Aprotinin in einem grossen Patientenkollektiv zu untersuchen. Im Zeitraum von 1995 bis 2003 wurden 12403 Operationen am Deutschen Herzzentrum München unter Einsat...    »
 
Translated abstract:
The non-specific proteinase inhibitor aprotinin is widely used in cardiac surgery to reduce bleeding. This protein has antigenic properties and hypersensitivity reactions may occur. The aim of this work is to evaluate the incidence of anaphylactic reactions to aprotinin in a large single center database. Of 13315 operations 12403 were done with aprotinin. Of this 12403 exposures 11602 were primary exposures and 801 were reexposures. 11 reactions to aprotinin were recorded after primary exposure (11/11602 = 0,1%), of which none was severe, while 12 reactions - 5 of them severe - occurred during reexposure (12/801 = 1,5%). There is a significant time dependent risk of allergic reactions during aprotininreexposure: respectively 4,1%, 1,9% and 0,4% in the < 6 months, 6-12 months and > 12 months reexposure intervals. Therefore aprotininreexposures during the first 6 months are strictly contraindicated. At a later date the drug can be given if the risk of bleeding is high and precautions are taken. 
Oral examination:
16.01.2008 
Pages:
82 
Last change:
07.03.2008