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- Original title:
- ADAM15 decreases RGD-dependent integrin alpha-v-beta-3-mediated ovarian cancer cell adhesion to vitronectin without affecting cell proliferative activity
- Translated title:
- ADAM15 reduziert RGD-abhängige, integrin alpha-v-beta-3 vermittelte Adhäsion von Ovarialkarzinomzellen zu Vitronectin ohne deren proliferative Aktivität zu beeinflussen
- Author:
- Herold, Hannes Florian
- Year:
- 2007
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Reuning, Ute (Priv.-Doz. Dr.)
- Referee:
- Reuning, Ute (Priv.-Doz. Dr.); Schmalfeldt, Barbara (Prof. Dr.)
- Language:
- en
- Subject group:
- MED Medizin
- Keywords:
- ADAM15, alpha-v-beta-3, vitronectin, adhesion, proliferation
- Translated keywords:
- ADAM15, alpha-v-beta-3, vitronectin, adhäsion, proliferation
- Abstract:
- ADAM15 overexpressing ovarian cancer cells show a significantly reduced adhesion to the ECM protein vitronectin in an RGD-integrin alpha-v-beta-3-dependent manner. The proliferative activity of the ovarian cancer cells remains unaffected. ADAM15 could thus function as a naturally occurring integrin alpha-v-beta-3 antagonist
- Translated abstract:
- ADAM15 überexprimierende Ovarialkarzinomzellen zeigen eine signifikant reduzierte, integrin alpha-v-beta-3-RGD-abhängige Adhäsion auf dem ECM-Protein Vitronectin. Die proliferative Aktivität bleibt unbeeinflusst. ADAM 15 könnte somit als natürlicher Integrin alpha-v-beta-3-Antagonist fungieren.
- WWW:
- https://mediatum.ub.tum.de/?id=619052
- Date of submission:
- 04.09.2006
- Oral examination:
- 24.01.2007
- File size:
- 6370242 bytes
- Pages:
- 81
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20070124-619052-0-5
- Last change:
- 27.04.2007
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