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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Aguilar-Pimentel, Juan Antonio; Cho, Yi-Li; Gerlini, Raffaele; Calzada-Wack, Julia; Wimmer, Maria; Mayer-Kuckuk, Philipp; Adler, Thure; Schmidt-Weber, Carsten B; Busch, Dirk H; Fuchs, Helmut; Gailus-Durner, Valérie; Ollert, Markus; Hrabě de Angelis, Martin; Ohlsson, Claes; Poutanen, Matti; Teperino, Raffaele; Strauss, Leena 
Title:
Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice. 
Abstract:
Sex steroids, such as estrogens and androgens, are important regulators of the humoral immune response. Studies in female mice have demonstrated that alteration of circulating estrogen concentration regulates antibody-mediated immunity. As males have normally little endogenous estrogen, we hypothesized that in males high estrogens and low androgens affect the immune system and enhance the allergic inflammatory response. Here, we studied transgenic male mice expressing human aromatase (AROM+). Th...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2020 
Journal volume:
10 
Journal issue:
Print-ISSN:
2045-2322 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Molekulare Allergologie (Prof. Schmidt-Weber)