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Document type:
Journal Article; Review 
Author(s):
Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D 
Title:
Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates. 
Abstract:
The continued global growth in the prevalence of obesity coupled with the limited number of efficacious and safe treatment options elevates the importance of innovative pharmaceutical approaches. Combinatorial strategies that harness the metabolic benefits of multiple hormonal mechanisms have emerged at the preclinical and more recently clinical stages of drug development. A priority has been anti-obesity unimolecular peptides that function as balanced, high potency poly-agonists at two or all t...    »
 
Journal title abbreviation:
Peptides 
Year:
2020 
Journal volume:
125 
Print-ISSN:
0196-9781 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)