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Document type:
Journal Article 
Author(s):
Jall, Sigrid; De Angelis, Meri; Lundsgaard, Anne-Marie; Fritzen, Andreas M; Nicolaisen, Trine S; Klein, Anders B; Novikoff, Aaron; Sachs, Stephan; Richter, Erik A; Kiens, Bente; Schramm, Karl-Werner; Tschöp, Matthias H; Stemmer, Kerstin; Clemmensen, Christoffer; Müller, Timo D; Kleinert, Maximilian 
Title:
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity. 
Abstract:
AIMS/HYPOTHESIS: Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but the physiological and molecular mechanisms are unknown. METHODS: DMPP (10 mg/kg body weight, s.c.) was administered either in a single injection (acute) or daily for up to 14 days (chronic) in DIO wild-type (WT) and Chrnb4 knockout (KO) mice and glucose tolerance, tissue-specific tracer-based g...    »
 
Journal title abbreviation:
Diabetologia 
Year:
2020 
Journal volume:
63 
Journal issue:
Pages contribution:
1236-1247 
Print-ISSN:
0012-186X 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)