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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Tian, Weili; Czopka, Tim; López-Schier, Hernán 
Title:
Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration. 
Abstract:
Protecting the nervous system from chronic effects of physical and chemical stress is a pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for Wallerian axon degeneration. Thus, blocking Sarm1 function is emerging as a promising neuroprotective strategy with therapeutic relevance. Yet, the conditions that will most benefit from inhibiting Sarm1 remain undefined. Here we combine genome engineering, pharmacology and high-resolution intravital videmicroscopy in ze...    »
 
Journal title abbreviation:
Commun Biol 
Year:
2020 
Journal volume:
Journal issue:
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)