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Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review 
Author(s):
Wanderoy, Simone; Hees, J Tabitha; Klesse, Ramona; Edlich, Frank; Harbauer, Angelika B 
Title:
Kill one or kill the many: interplay between mitophagy and apoptosis. 
Abstract:
Mitochondria are key players of cellular metabolism, Ca2+ homeostasis, and apoptosis. The functionality of mitochondria is tightly regulated, and dysfunctional mitochondria are removed via mitophagy, a specialized form of autophagy that is compromised in hereditary forms of Parkinson's disease. Through mitophagy, cells are able to cope with mitochondrial stress until the damage becomes too great, which leads to the activation of pro-apoptotic BCL-2 family proteins located on the outer mitochondr...    »
 
Journal title abbreviation:
Biol Chem 
Year:
2020 
Journal volume:
402 
Journal issue:
Pages contribution:
73-88 
Fulltext / DOI:
Print-ISSN:
1431-6730 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)